González returned to the Major Leagues with the Cincinnati Reds sometime in 1914 and went on to play 16 more seasons (1914–21; 1924–29; 1931–32) with the St. Louis Cardinals (in three separate stints), New York Giants and Chicago Cubs, batting .253 in 1,042 games. He appeared in one World Series - 1929 with the Cubs - and was hitless in his only at-bat.
In 1933, he became a coach for the Cardinals' American Association farm club, the Columbus Red Birds, and joined the St. Louis coaching staff in 1934 under manager Frankie Frisch. It was the year of the "Gashouse Gang," the hard-playing Cardinal team that stormed to the NL pennant and a seven-game Fall Classic triumph over the Detroit Tigers. González coached under Frisch until September 14, 1938, when Frisch was fired. González then took the helm for the final 16 games of the season, leading the Cardinals to an 8–8 record. He resumed his coaching role under Ray Blades the following season, but again became the Cards' acting pilot on June 7, 1940, handling the team until June 10, when Blades' permanent successor, Billy Southworth, arrived from Rochester. Overall, González' big-league managing record was nine wins and 13 defeats (.409).
González continued on the Cardinals' coaching lines through 1946. In the bottom of the eighth inning of his final game, the seventh and deciding contest of the 1946 World Series, Gonzalez was coaching at third base when Enos Slaughter raced home from first base on a double by Harry Walker. "Slaughter's Mad Dash" scored the winning run and earned the Cardinals the world championship. Although films taken of the play appear to show González waving Slaughter in, other accounts report that Slaughter ignored the coach's stop sign and took home on his own initiative.
González is credited with contributing a lasting piece of baseball terminology. Asked by the Cardinals to scout a winter league player, González judged that the player was outstanding defensively but a liability as a batter. He wired back a four-word scouting report: "Good field, no hit." That phrase is still in use today.
After the Cuban Revolution brought Fidel Castro to power in 1959, and the ensuing chill in relations between Cuba and the U.S., González remained in Cuba, where he was cut off from his old friends and associates in American baseball. He died in Havana at age 86 in 1977.